Opportunity Information: Apply for CDC RFA PS19 1905
The CDC, through the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), offered this cooperative agreement funding opportunity (CDC RFA PS19-1905) to strengthen the use of epidemiologic and economic modeling to guide real-world public health decisions. The core purpose is to develop and apply scientifically sound disease transmission and cost-effectiveness models that can help public health leaders understand what interventions are likely to prevent the most infections, reduce illness, and make the best use of limited resources. In practical terms, the opportunity is about turning surveillance data, program data, and research evidence into forward-looking projections and economic comparisons that can inform which strategies should be implemented, scaled, or prioritized.
The modeling focus spans several interconnected program areas: HIV, viral hepatitis, sexually transmitted diseases, and tuberculosis, and it also references school health as part of the broader prevention context. The CDC highlights disease transmission models because they can estimate how infections spread under different assumptions (for example, changes in testing coverage, treatment uptake, partner services, vaccination, harm reduction, or outbreak response). Alongside this, economic models, including cost-effectiveness analyses, are emphasized because they help quantify tradeoffs between intervention costs and expected health benefits, such as infections averted, improved quality of life, or reduced downstream medical spending. The overall goal is to improve prevention effectiveness, meaning the CDC wants models that can meaningfully support decision-making rather than purely academic exercises.
This was published as a discretionary funding opportunity using a cooperative agreement mechanism, which usually implies substantial involvement from the funding agency during the project period. Rather than simply funding an independent research project, a cooperative agreement typically expects collaboration with CDC staff, alignment with CDC priorities, and iterative communication around methods, assumptions, and deliverables. The opportunity was open to a broad range of applicants (listed as unrestricted eligibility), subject to any additional eligibility details that may have appeared in the full announcement.
Administratively, the opportunity was created on January 28, 2019, with an original closing date of April 14, 2019, and applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date. The agency anticipated making approximately three awards. The notice lists an award ceiling of 0, which commonly indicates that a fixed cap was not specified in the summary field and that the actual funding levels would be detailed elsewhere in the full announcement or depend on available appropriations and CDC decisions.
In summary, this grant opportunity was designed to expand the CDCs and jurisdictions ability to use credible modeling to evaluate prevention strategies across HIV, hepatitis, STDs, and TB. By supporting the development and application of transmission and economic models, the CDC aimed to help state and local partners plan, prioritize, and justify interventions based on projected public health impact and value for money, ultimately improving the effectiveness of prevention programs and guiding resource allocation.Apply for CDC RFA PS19 1905
- The Department of Health and Human Services, Centers for Disease Control - NCHHSTP in the health sector is offering a public funding opportunity titled "Economic Modeling for HIV/AIDS, Viral Hepatitis, STD, and TB" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Jan 28, 2019.
- Applicants must submit their applications by Apr 14, 2019 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is CDC RFA PS19-1905?
CDC RFA PS19-1905 is a CDC cooperative agreement funding opportunity offered through the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP). Its purpose is to strengthen how epidemiologic (disease transmission) and economic modeling are used to support real-world public health decisions.
What is the main purpose of this funding opportunity?
The core purpose is to develop and apply scientifically sound disease transmission and cost-effectiveness models that help public health leaders compare prevention strategies, estimate impacts (such as infections prevented or illness reduced), and make better use of limited resources.
What kinds of modeling does the CDC emphasize in this opportunity?
The opportunity emphasizes two related model types: (1) disease transmission models that project how infections may spread under different conditions and interventions, and (2) economic models, including cost-effectiveness analyses, that compare intervention costs against expected health benefits and potential downstream medical savings.
What decisions are these models meant to inform?
These models are intended to help decision-makers determine which interventions should be implemented, scaled, or prioritized. The goal is to produce forward-looking projections and economic comparisons that support practical planning and resource allocation, not modeling that is purely academic.
Which public health program areas are included?
The modeling focus spans several interconnected areas: HIV, viral hepatitis, sexually transmitted diseases (STDs), and tuberculosis (TB). The opportunity also references school health as part of the broader prevention context.
What types of data and evidence are expected to feed into the models?
The opportunity is framed around turning surveillance data, program data, and research evidence into projections and economic comparisons that can guide prevention strategies.
What are examples of intervention scenarios that transmission models might examine?
The CDC highlights that transmission models can estimate how infections spread under different assumptions, including changes in testing coverage, treatment uptake, partner services, vaccination, harm reduction, or outbreak response.
Why does the opportunity include economic modeling and cost-effectiveness analysis?
Economic models are emphasized to quantify tradeoffs between the costs of interventions and expected benefits, such as infections averted, improved quality of life, or reduced downstream medical spending. This helps leaders justify and prioritize strategies when resources are limited.
What does the CDC mean by improving prevention effectiveness?
In this context, improving prevention effectiveness means using models to meaningfully support decision-making about prevention programs, including selecting and prioritizing strategies based on projected impact and value.
What funding mechanism was used?
This was published as a discretionary funding opportunity using a cooperative agreement mechanism.
What does it mean that this is a cooperative agreement?
A cooperative agreement typically implies substantial involvement from the funding agency during the project period. Rather than operating entirely independently, recipients generally should expect collaboration with CDC staff, alignment with CDC priorities, and iterative communication about methods, assumptions, and deliverables.
Who was eligible to apply?
The opportunity was open to a broad range of applicants and was described as having unrestricted eligibility, subject to any additional eligibility details that may have been included in the full announcement.
When was the opportunity created and when did it close?
The opportunity was created on January 28, 2019. The original closing date was April 14, 2019.
What was the application submission deadline time and time zone?
Applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date.
How many awards did the CDC anticipate making?
The CDC anticipated making approximately three awards.
Was there a maximum (ceiling) award amount listed?
The notice lists an award ceiling of 0. In this context, that commonly indicates a fixed cap was not specified in the summary field, and actual funding levels would be detailed elsewhere in the full announcement or depend on appropriations and CDC decisions.
What outcomes is the CDC aiming for by funding this work?
The overarching aim is to expand the CDC's and jurisdictions' ability to use credible modeling to evaluate prevention strategies across HIV, hepatitis, STDs, and TB, and to help state and local partners plan, prioritize, and justify interventions based on projected impact and value.
Is the emphasis more on research or on practical decision support?
The opportunity emphasizes practical decision support. It focuses on models that can guide real-world public health decisions and improve prevention program effectiveness, rather than modeling efforts that are primarily academic exercises.
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