Opportunity Information: Apply for PAR 23 138
The Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed), listed as NIH funding opportunity PAR-23-138, is a discretionary federal grant program designed to help resource-limited institutions buy modern, state-of-the-art scientific instruments. The central purpose is to strengthen an institution's research and educational capacity by improving access to shared, high-end equipment that can be used to support a broad range of biomedical work. NIH frames the scope broadly, allowing instruments that will advance basic research, translational research, and biomedically related behavioral or clinical research and education, as long as the application fits within the program rules and the overall mission of NIH.
This opportunity is specifically focused on instrumentation rather than funding individual research projects. In practice, that means the core request is for the purchase of a major instrument (or instruments, depending on the program's allowable structure), with a strong justification for why the equipment is needed, how it will be used, who will use it, and how it will expand or modernize research and training capabilities at the applicant institution. The emphasis on "resource-limited" institutions signals that NIH is aiming to increase equitable access to cutting-edge research infrastructure, particularly for organizations that may not have the same capital resources as larger, research-intensive institutions.
The eligible applicant landscape is broad and includes many types of U.S.-based organizations and governmental units. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The opportunity also explicitly highlights additional eligible categories often associated with serving historically under-resourced communities, including Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; and U.S. territories or possessions.
At the same time, there are clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. These limitations mean that the applicant organization and the supported activities need to be fully domestic in the NIH sense, without foreign subawards, foreign performance sites, or foreign organizational components in the project structure.
The activity category is Health and the funding instrument type is a Grant. The opportunity is associated with multiple CFDA numbers (now commonly referred to under assistance listing structures), including 93.121, 93.172, 93.173, 93.242, 93.273, 93.286, 93.307, 93.310, 93.350, 93.351, 93.846, 93.859, 93.866, and 93.867, reflecting that NIH institutes and centers across different mission areas may participate in supporting awards under this umbrella.
A key compliance point is embedded in the title: "Clinical Trial Not Allowed." That indicates applications cannot propose clinical trials as part of the funded work. While the instruments may support clinical or clinically related research and education in a general sense, the funded project itself cannot be structured around conducting a clinical trial. Applicants typically need to ensure their described uses, user groups, and planned activities remain consistent with an instrumentation acquisition and shared-use framework rather than a trial-based intervention study.
The opportunity was created on March 21, 2023, and the original closing date listed is June 2, 2025. Although the posting does not provide an award ceiling or expected number of awards in the supplied text, the practical takeaway is that interested institutions should plan well ahead of the deadline to assemble a strong justification for the instrument purchase, demonstrate institutional need and readiness, and clearly explain how the equipment will enhance both research productivity and educational outcomes for the communities and programs the institution serves.Apply for PAR 23 138
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.173, 93.242, 93.273, 93.286, 93.307, 93.310, 93.350, 93.351, 93.846, 93.859, 93.866, 93.867.
- This funding opportunity was created on 2023-03-21.
- Applicants must submit their applications by 2025-06-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Defining Mechanisms of HIV Induced Inflammation and Immune Activation During Suppressive Antiretroviral Therapy (ART) (R01 Clinical Trial Not Allowed) Apply for RFA AI 23 018 Funding Number: RFA AI 23 018 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| NIH Directors Transformative Research Awards (R01 Clinical Trial Optional) Apply for RFA RM 23 006 Funding Number: RFA RM 23 006 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Suicide Prevention Across the Life Span in Low- and Middle-Income Countries (R34 Clinical Trial Optional) Apply for RFA MH 23 260 Funding Number: RFA MH 23 260 Agency: National Institutes of Health Category: Health Funding Amount: $450,000 |
| NIH Directors Early Independence Awards (DP5 Clinical Trial Optional) Apply for RFA RM 23 007 Funding Number: RFA RM 23 007 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Understanding Neurological Effects of COVID-19 and Post-Acute Sequelae of SARS-CoV-2 Infection (R01 Clinical Trial Optional) Apply for RFA NS 23 021 Funding Number: RFA NS 23 021 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NIH Directors New Innovator Award Program (DP2 Clinical Trial Optional) Apply for RFA RM 23 005 Funding Number: RFA RM 23 005 Agency: National Institutes of Health Category: Health Funding Amount: $900,000 |
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| Animal Models for Hepatitis B and C (R01 Clinical Trial Not Allowed) Apply for RFA AI 23 022 Funding Number: RFA AI 23 022 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCR Research Grants for Analyses of Existing Genomics Data (R01) (Clinical Trial Not Allowed) Apply for PAR 23 133 Funding Number: PAR 23 133 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Understanding Neurological Effects of COVID-19 and Post-Acute Sequelae of SARS-CoV-2 Infection (R21 Clinical Trial Optional) Apply for RFA NS 23 022 Funding Number: RFA NS 23 022 Agency: National Institutes of Health Category: Health Funding Amount: $275,000 |
| Pulmonary Outcomes and Sequelae after Treatment-TB (POST-TB) (R01 Clinical Trial Optional) Apply for PAR 23 148 Funding Number: PAR 23 148 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Developing Measures to Advance Access and Quality in Global Mental Health Services (R34 Clinical Trial Not Allowed) Apply for RFA MH 23 300 Funding Number: RFA MH 23 300 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Implementing and Evaluating New Models for Delivering Comprehensive, Coordinated, Person-Centered Care to People with Long COVID (U18) Apply for RFA HS 23 012 Funding Number: RFA HS 23 012 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRCs) (U54 Clinical Trial Optional) Apply for RFA NS 24 022 Funding Number: RFA NS 24 022 Agency: National Institutes of Health Category: Health Funding Amount: $1,200,000 |
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